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Efficacy of Efepoetin Alfa for Chemotherapy-Induced Anemia in Breast Cancer Patients: Case Series
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| Pengarang | : | Zainal Abidin, Anova Fatimah |
| Nama Majalah/Jurnal | : | CDK Cermin dunia kedokteran |
| Volume / Edisi | : | 52 (No. 12) |
| Halaman | : | 803-807 |
| Abstrak | : | Anemia is a common complication among cancer patients and substantially reduces quality of life (QOL) through symptoms such as fatigue and cognitive impairment. This case evaluates the use of efepoetin alfa to treat chemotherapy?induced anemia (CIA) in late?stage breast cancer patients in Indonesia. Case: Six Asian women aged 43–59 years with stage III breast cancer receiving docetaxel?doxorubicin chemotherapy developed moderate anemia (mean baseline hemoglobin [Hb] 9.5 g/dL). Patients received subcutaneous efepoetin alfa (generally 0.3 mg/0.3 mL once); Hb was reassessed at an average of 8 days after the last injection. Discussion: Post?treatment mean Hb rose to 12.1 g/dL (mean ΔHb ≈ 2.6 g/dL). No serious adverse events were observed during the short follow?up. Conclusion: In this case, efepoetin alfa was associated with rapid increases in Hb and improved patient?reported outcomes; however, a confirmatory larger study, standardized dosing and monitoring, and longer follow?up are required to define efficacy and long?term safety. |
Physical Exercise for Reducing Intraocular Pressure in Glaucoma
| Pengarang | : | Suhada, Hendrata |
| Nama Majalah/Jurnal | : | CDK Cermin dunia kedokteran |
| Volume / Edisi | : | 52 (No. 12) |
| Halaman | : | 795-802 |
| Abstrak | : | Glaucoma is a common eye condition that poses a risk to vision, as it involves elevated intraocular pressure (IOP) and can lead to vision impairment. Elevated intraocular pressure (IOP) and inadequate ocular perfusion are the basic theories of glaucoma development and progression. Methods: Literature within the last 10 years was searched through PubMed and Googleusing the specified keywords: “Glaucoma” (title), “Intraocular Pressure (IOP)” (all fields), and “Physical Exercise” (all fields). The PRISMA method is used to process journal selection. Results: Dynamic exercises such as cycling and jogging have been shown to significantly reduce intraocular pressure (IOP), particularly in patients with glaucoma, whereas isometric activities like weightlifting or head-down yoga poses temporarily increase IOP. Breathing exercises such as yogic pranayama can lower IOP by stimulating parasympathetic activity and improving aqueous humor outflow without elevating ocular venous pressure. Conclusion: The decrease in IOP and increase in OPP after dynamic exercises such as cycling and jogging were related to the intensity of the exercise. No cure is available; management is to prevent further damage and vision loss. Physical exercise influences the IOP, ocular perfusion, neuroprotection, and mental health in patients with glaucoma. This article discusses the benefits of physical exercise in reducing IOP and its potential risks in glaucoma patients. |
Quality of Life of Elderly Patients with Low Back Pain at Ulin General Hospital Banjarmasin
| Pengarang | : | Tjitro, Soejono |
| Nama Majalah/Jurnal | : | CDK Cermin dunia kedokteran |
| Volume / Edisi | : | 52 (No. 12) |
| Halaman | : | 789-794 |
| Abstrak | : | Low back pain can change the daily life and quality of life of the elderly. This study aims to determine the quality of life of elderly patients with and without low back pain at Ulin General Hospital Banjarmasin. Methods: This study used an analytical observational approach with a cross?sectional design. Sampling was through a purposive sampling approach according to the inclusion criteria. The study population was 100 patients aged 60 and over, half of the population with low back pain. The Indonesian versions of the WHOQoL?BREF and SF?36 questionnaires were used as a research instrument. Results: The results showed significant differences in the quality of life in the elderly patients with low back pain in 4 domains, namely physical functioning (p = 0.006), role limitations due to physical health (p = 0.023), social functioning (p = 0.009), and general health (p < 0.001), with median of each domain in order are 62,5 (0–100), 50 (0–100), 75 (0–100), and 50 (4–100). No significant differences in other domains in the WHOQoL-BREF and SF-36 questionnaire. Conclusion: Low back pain affects the life of elderly patients at Ulin General Hospital Banjarmasin, which was different in 4 aspects, namely physical functioning, role limitations due to physical health, social functioning, and general health. |
Private Practitioners Perceptions of the Tuberculosis Case Reporting System in Pontianak City in 2020
| Pengarang | : | Namira Alifah Fahiratunnisa, Agus Fitriangga, Raharjo Raharjo |
| Nama Majalah/Jurnal | : | CDK Cermin dunia kedokteran |
| Volume / Edisi | : | 52 (No. 12) |
| Halaman | : | 782-788 |
| Abstrak | : | In reality, many tuberculosis (TB) patients don’t receive proper treatment. One contributing factor is the high number of unreported tuberculosis cases. This study aims to understand the perception of independent practice doctors regarding tuberculosis case reporting in Pontianak City in 2020. Method: This research uses a qualitative approach with a case study design. The research sample consists of 12 independent practice doctors from each district in Pontianak City, as well as TB program managers. The sample was determined using purposive sampling technique, and qualitative data were analyzed using content analysis. Results: The study results indicate a lack of knowledge and understanding in the private sector regarding the Minister of Health Regulation Number 67 of 2016 related to the case reporting system. Conclusion: Key factors in the underreporting of TB cases to independent practitioners include public health centers serving as the primary referral for TB patients. Additionally, there is limited knowledge and understanding of the Minister of Health Regulation Number 67 of 2016 and its implementation, a lack of coordination and socialization from the government, both directly and indirectly, to general practitioner, and uncooperative patients in TB case management. |
Antibacterial Activity Test of the Combination of Binahong Leaf Extract (Anredera cordifolia (Ten.) Steenis) and Moringa Leaf Extract (Moringa oleifera Lam.) against Propionibacterium acnes, the Bacteria that Causes Acne
| Pengarang | : | Mela Agustina, Nopi Anggista Putri, Wina Safutri, Iga Mayola Pisacha |
| Nama Majalah/Jurnal | : | CDK Cermin dunia kedokteran |
| Volume / Edisi | : | 52 (No. 12) |
| Halaman | : | 773-781 |
| Abstrak | : | Acne is a skin disease that is often found in many teenagers to young adults. Propionibacterium acnes is one of the causes of acne infection with a prevalence of 12.9%. As long-term inappropriate use of antibiotics can cause resistance, traditional medicine using natural ingredients can act as an alternative. The secondary metabolite compounds from binahong (Anredera cordifolia (Ten.) Steenis) leaves and moringa (Moringa oleifera Lam.) leaves are believed to have antibacterial activity. This study aims to determine the antibacterial activity of a combination of binahong leaves and moringa leaves in inhibiting the growth of acne-causing bacteria, Propionibacterium acnes. Methods: This quantitative experimental research study tested the antibacterial properties of binahong leaves and moringa leaves againstPropionibacterium acne with random design (RAL) of 11 treatments with 3 repetitions. Bacterial test used paper disc diffusion with a single concentration of 20%, 40%, 60% and a combination of 20%:20%, 40%:60%, and 60%:40%, with clindamycin as positive control and sterile aquadest as negative control. Results: The phytochemical screening results were that binahong leaves and moringa leaves contained alkaloids, tannins, saponins, and flavonoids while the results of the antibacterial activity test were that the 60%:40% combination was more effective in inhibiting the growth of Propionibacterium acnes with an inhibition zone diameter of 26.7 mm ± 2.0 (strong). Conclusion: Binahong leaves and Moringa leaves contain secondary metabolite compounds of tannins, alkaloids, saponins, and flavonoids, and have antibacterial activity. Binahong leaves and moringa leaves can inhibit the growth of bacterium Propionibacterium acnes with a strong inhibition zone category. |
Radiological Features of Inflammatory Arthritis
| Pengarang | : | Liem Marcella Nathania, Erina Damayanti Ligin |
| Nama Majalah/Jurnal | : | CDK Cermin dunia kedokteran |
| Volume / Edisi | : | 52 (No. 11) |
| Halaman | : | 766-772 |
| Abstrak | : | Arthritis is a common disease that often causes activity limitations. The diagnosis of inflammatory arthritis requires conventional radiography as the primary modality. Assessment of alignment (A), bone (B), cartilage loss (C), demineralization (D), erosion (E), and soft tissue swelling (S) on radiographs is necessary to differentiate the three most common inflammatory arthritides: rheumatoidarthritis, gouty arthritis, and psoriatic arthritis (PsA). Each type of arthritis has characteristic radiological features that are important for diagnosis. Rheumatoid arthritis is characterized by marginal erosion in bare areas, periarticular osteopenia, and uniform joint space narrowing with bilateral symmetrical distribution. Gouty arthritis shows punched-out erosion with overhanging edges, tophi deposits, and normal bone mineralization. Psoriatic arthritis has characteristic marginal erosions accompanied by new bone formation, pencilin- cup deformities, and dactylitis. Understanding the differences in the radiological features of these three diseases is important for establishing an accurate diagnosis and determining appropriate therapy. The combination of radiographic examination with clinical and laboratory data is expected to improve diagnostic accuracy and reduce disease progression. |
Phlebotomy in Cyanotic Adult Congenital Heart Disease
| Pengarang | : | Ngurah Agung Reza Satria Nugraha, I Ketut Susila |
| Nama Majalah/Jurnal | : | CDK Cermin dunia kedokteran |
| Volume / Edisi | : | 52 (No. 11) |
| Halaman | : | 756-765 |
| Abstrak | : | Adult congenital heart disease is a cardiovascular condition that necessitates a comprehensive approach to medical and surgical intervention. In this condition, cyanosis results from a right-to-left shunt, which subsequently causes secondary erythrocytosis and hyperviscosity. Dehydration and iron deficiency can exacerbate the symptoms of hyperviscosity. One proposed strategy for reducingviscosity is phlebotomy. Phlebotomy procedures should be conducted with adequate fluid replacement to prevent acute stroke. While phlebotomy can reduce red blood cell mass and serum viscosity, it should be performed judiciously and not repeatedly to avoid stroke complications. Repeated phlebotomy without appropriate indications may lead to chronic iron deficiency and microcytic erythrocytes, which paradoxically increase the risk of cerebrovascular complications. Indications for therapeutic phlebotomy include moderate to severe hyperviscosity symptoms with hematocrit levels of at least 65% in the absence of dehydration or iron deficiency.The benefits of phlebotomy should only be considered when appropriate indications are met to achieve improved patient outcomes. |
The Development of Teledermoscopy in Indonesia: A Review from a Health Law Perspective
| Pengarang | : | - |
| Nama Majalah/Jurnal | : | CDK Cermin dunia kedokteran |
| Volume / Edisi | : | 52 (No. 11) |
| Halaman | : | 751-755 |
| Abstrak | : | Teledermoscopy, as a component of telemedicine, represents an important innovation in dermatological healthcare that enhances accessibility, effectiveness, and the overall quality of medical services in Indonesia. This technology provides significant benefits, particularly for communities in regions with limited access to dermatology specialists. Law Number 17 of 2023 concerning Health and Government Regulation Number 28 of 2024 serve as the primary legal foundations supporting the implementation of teledermoscopy in Indonesia. These regulations address the legality of practice, patient data protection, information security standards, and the responsibilities of healthcare professionals and electronic system providers in delivering digital health services. Teledermoscopyenables remote examination, diagnosis, and monitoring of skin lesions through digital dermoscopy devices connected to the national health information system. The technology accelerates diagnosis, facilitates referrals, and broadens access to dermatological care. With a robust legal framework, continuous professional training, and reliable digital infrastructure, teledermoscopy has the potential to become a strategic component in the transformation of Indonesia’s national healthcare system. |
Vaccination as a Preventive Measure Against Foodborne Diseases in Children
| Pengarang | : | Pika Novriani Lubis |
| Nama Majalah/Jurnal | : | CDK Cermin dunia kedokteran |
| Volume / Edisi | : | 52 (No. 11) |
| Halaman | : | 745-750 |
| Abstrak | : | Foodborne disease is one of the disease burdens because it can lead to disability and mortality, particularly in children. Hepatitis A and typhoid are the primary causes of foodborne diseases in developing countries. Although the majority will recover, children with hepatitis A can be a source of transmission. Meanwhile, in addition to endemicity in Indonesia, antibiotic resistance to typhoid infections is rising. Vaccination is considered an economic measure to suppress the incidence and transmission of disease, as well as prevent outbreaks. To achieve the effectiveness and efficiency of vaccination, it is essential for the general practitioner to have a comprehensive understanding of the preparations, methods of use, storage, precautions, contraindications, and potential adverse effects of the vaccine. In addition, increased public awareness of the importance of vaccination and the implementation of good food hygiene are factors that support the success of foodborne disease prevention. Public education efforts through health facilities and schools need to be strengthened to expand childhood immunization coverage. Thus, it is hoped that the incidence of hepatitis A and typhoid can be significantly reduced, in line with national and global health program targets to reduce morbidity and mortality rates from vaccine-preventable diseases. |
The Effect of Amino Acid Administration in Preventing Acute Kidney Injury (AKI) Following Cardiac Surgery
| Pengarang | : | Lukman Nur Rahman, Munzir Makarim, Muh. Azrief Khaidir Anjar, Muh. Syawaludin Sakti Maulana, Rais Trisiyambudin, Greyson Efraldi Sampe, Rifal Faali, Muhammad Hilmi Falah, Muh. Ikmaluddin Furqon, Dzar Ghifari Muh Rizal |
| Nama Majalah/Jurnal | : | CDK Cermin dunia kedokteran |
| Volume / Edisi | : | 52 (No. 11) |
| Halaman | : | 738-744 |
| Abstrak | : | The administration of amino acids can be a safe and effective approach to reducing the risk of acute kidney injury (AKI) following cardiac surgery. Methods: In this systematic review, data were obtained from scientific databases PubMed, ProQuest, ScienceDirect, and Google Scholar, covering publications from January 1 to November 1, 2024. This systematic review analyzed 3 randomized controlled trials involving a total of 3,647 patients. Results: AKI was observed in 26.6% patients in the amino acid group compared to 31.9% in the control group (RR = 0.67; 95% CI [0.43–1.06]; I² = 52.5%; p = 0.0854). Additionally, the risk of stage 1 AKI (21.1% vs 24.5%; RR 0.86; 95% CI [0.77–0.96]; I² = 0%) and stage 3 AKI (0.15% vs 0.3%; RR 0.52; 95% CI [0.34–0.81]; I² = 0%) was significantly lower in the amino acid group. No serious adverse events were reported in the included studies. Risk of bias was assessed using the Cochrane Risk of Bias-2 (RoB2) tool, and data analysis was performed using R software. Conclusion: Findings suggest that amino acids offer clinical benefits in AKI prevention, particularly in stages 1 and 3, without increasing the risk of severe adverse effects |