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Telomerase Inhibitor: Promising Target Therapy for Cancer
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| Pengarang | : | Diana Kusuma, Izza Aliya, Andre Putra, Mediana Sutopo |
| Nama Majalah/Jurnal | : | CDK Cermin dunia kedokteran |
| Volume / Edisi | : | 45 (No. 4) |
| Halaman | : | 304-308 |
| Abstrak | : | The key to selectively targeting cancer cells is to exploit some basic differences with their normal precursors. One such difference is the activity of the enzyme telomerase. Some studies targeted telomerase and telomeres in order to block limitless replicative potential of cancer cells, providing a fascinating strategy for a broad-spectrum cancer therapy. Telomerase based therapies could be well tolerated and perhaps with minimal side effect on telomerase-competent stem cells. |
Pemeriksaan Radiologi untuk Deteksi Kanker Ovarium
| Pengarang | : | Ni Made Putri Suastari |
| Nama Majalah/Jurnal | : | CDK Cermin dunia kedokteran |
| Volume / Edisi | : | 45 (No. 4) |
| Halaman | : | 298-302 |
| Abstrak | : | Ovarian cancer is the second most frequent gynecology cancer in the world. Several risk factors are associated with ovarian cancer, but the exact cause is still unknown. Combination of various medical imaging modalities such as USG, CT scan, PET scan, and MRI can be utilized for early detection that can improve survival. |
Tren Terapi Diabetes dengan GLP-1 Receptor Agonist
| Pengarang | : | Pande Made S. Dharma Pathni |
| Nama Majalah/Jurnal | : | CDK Cermin dunia kedokteran |
| Volume / Edisi | : | 45 (No. 4) |
| Halaman | : | 291-296 |
| Abstrak | : | GLP-1 becomes a therapeutic target of type 2 DM. Analogue of GLP-1 has the activity that mimics endogenous GLP-1, with advantages to be resistant to DPP-4 enzyme deactivation, resulting in longer activity. Other activities of this class are to lower glucagon hormone level, slow gastric emptying and induce satiety. |
Herpes Zoster Lumbalis Sinistra pada Pasien Terinfeksi HIV
| Pengarang | : | |
| Nama Majalah/Jurnal | : | CDK Cermin dunia kedokteran |
| Volume / Edisi | : | 45 (No. 4) |
| Halaman | : | 277-279 |
| Abstrak | : | Human Immunodeficiency Virus (HIV) may suppress the immune system. There is relationship between HIV infections with various skin manifestations. Herpes zoster is caused by reactivation and multiplication of varicella zoster virus in sensory ganglia after varicella. Case: A 32 year-old male with painful, clustered vesicle on erythematous base along left calf to foot since 3 days. He was diagnosed HIV positive 7 months ago. Physical examination showed herpetiform vesicles on erythematous base in left Lumbal 5 (L5) dermatome. Tzank test showed the presence of multinucleated giant cells. CD4 cell count is 212/μL. |
Sindrom Stevens-Johnson Diduga Akibat Fenitoin
| Pengarang | : | Herpes Zoster Lumbalis Sinistra pada Pasien |
| Nama Majalah/Jurnal | : | CDK Cermin dunia kedokteran |
| Volume / Edisi | : | 45 (No. 4) |
| Halaman | : | 272-275 |
| Abstrak | : | Stevens - Johnson syndrome (SJS) is a type of epidermal necrolysis (NE), a syndrome of acute mucocutaneus reaction recognized by widespread necrosis and epidermal lysis. A case of 21 year-old female, presented in emergency with fever and reddish rash followed by vesicles since 3 days. After phenytoin consumption, reddish spots with urticaria were observed in thigh, legs and back. Two days later, they were followed with vesicles spreading to whole body. Clinical improvement was observed after 9 days, and the patient was discharged. |
Pengaruh Stres Psikologis terhadap Kadar Testosteron Saliva Anak Masa Pubertas
| Pengarang | : | Dimas Bagus Prastyo, Melda Deliana, Siska Mayasari Lubis, Karina Sugih Arto |
| Nama Majalah/Jurnal | : | CDK Cermin dunia kedokteran |
| Volume / Edisi | : | 45 (No. 4) |
| Halaman | : | 266-270 |
| Abstrak | : | Puberty is an important stage in the child’s development; it is a complex biological process of sexual maturation. The process is influenced by genetic and environmental factors, like stress. Stress conditions can disrupt the reproductive system. Studies found that testosterone levels are affected by stress. Measurement of testosterone levels through saliva is not invasive and correlate with serum free testosterone levels. Salivary testosterone levels can potrays the effect of stress on the HPG axis during puberty. |
Cutaneous Larva Migrans
| Pengarang | : | Stevani Novita, Bangbang Buhari |
| Nama Majalah/Jurnal | : | CDK Cermin dunia kedokteran |
| Volume / Edisi | : | 45 (No. 3) |
| Halaman | : | 211-213 |
| Abstrak | : | Cutaneous larva migrans (CLM) is a skin disease caused by larva of hookworm from dogs and cats, most commonly Ancylostoma braziliense and Ancylostoma caninum. Larva penetrates skin surface, migrates through the epidermis, and leaves a characteristic linear or serpiginous rash forming a burrow commonly referred to as ‘creeping eruption’. We reported a case of a 48-year-old man with pruritic lesion on his left hand since a week ago. Physical examination revealed a serpiginous, skin-colored papule. Those findings confirmed the diagnosis of CLM. He was treated with a single dose of albendazole 400 mg for three days and an oral antihistamine. The lesion and symptom resolved 5 days after treatment. |
Penanda Tumor untuk Diagnosis Karsinoma Kaput Pankreas
| Pengarang | : | Irmayanti, Uleng Bahrun, A.M. Luthfi Parewangi, Ibrahim Abd. Samad |
| Nama Majalah/Jurnal | : | CDK Cermin dunia kedokteran |
| Volume / Edisi | : | 45 (No. 3) |
| Halaman | : | 207-210 |
| Abstrak | : | Carcinoma in the head of the pancreas tends to occur in the elderly age and it is the fourth leading cause of death due to malignancy. Diagnosis of this disease is made based on medical history, physical examination, laboratory, and radiology investigations. Case.Carcinoma in the head of the pancreas led to bile flow obstruction, causing cholestasis accompanied by pronounced increase of CEA and CA 19-9 values. |
Tatalaksana Juvenile Nasopharyngeal Angiofibroma
| Pengarang | : | Ni Made Ary Wisma Dewi |
| Nama Majalah/Jurnal | : | CDK Cermin dunia kedokteran |
| Volume / Edisi | : | 45 (No. 3) |
| Halaman | : | 202-205 |
| Abstrak | : | uvenile nasopharyngeal angiofibroma (JNA) is a histologically rare benign tumor. JNA is clinically malignant because has the ability to destruct bone and widely spread to surrounding tissues. JNA is generally silent for years. Patients are typically adolescent male. Diagnosis is based on history taking, physical examination, and radiologic findings. |
Patient–controlled Analgesia untuk Nyeri Akut pada Sickle Cell Vaso–occlusive Crisis
| Pengarang | : | I Made Prema Putra |
| Nama Majalah/Jurnal | : | CDK Cermin dunia kedokteran |
| Volume / Edisi | : | 45 (No. 3) |
| Halaman | : | 197-200 |
| Abstrak | : | Sickle cell disease/SCD still becomes global health problem. Severe acute pain in patient of SCD is commonly found clinical manifestation of vaso-occlusive crisis caused by sickle-shape of red blood cells, and leads to tissue occlusion and infarct. Assessment and treatment should be immediate. No pain treatments are superior to others. One of recommendation therapy for rapid severe acute pain control caused by vaso-occlusive crisis, is patient-controlled analgesia (PCA) with intravenous opioid, on-demand, or patient-controlled. |